A Step-by-Step Guide to Chronic Inflammatory Response Syndrome (CIRS) Treatment
At Functional GYN, we understand that CIRS (Chronic Inflammatory Response Syndrome) can be overwhelming. From identifying symptoms to developing a personalized treatment plan, this journey requires patience and commitment.
While every patient’s protocol is customized based on symptoms, environmental exposure, lab results, and genetics, this guide provides a broad overview of the key treatment phases.
Step 1: Remove Exposure & Detox Your Environment
The first and most crucial step in CIRS recovery is eliminating exposure to environmental toxins. Whether at work or home, exposure to mold, biotoxins, and other environmental triggers keeps the immune system in a constant state of overdrive, preventing healing.
🔹 Action Plan:
✔ Conduct environmental testing to identify mold, mycotoxins, or other biotoxins.
✔ Implement remediation measures or relocate if necessary.
✔ Begin lifestyle modifications to support detoxification naturally.
👉 Why It Matters: Until exposure is removed, the body remains in a constant inflammatory cycle, making it difficult to move forward in treatment.
Step 2: Reduce Inflammation to Prepare for Detox
Before deep detoxification begins, the body must be prepared by reducing systemic inflammation. This phase typically lasts about four weeks, though individual factors may extend or shorten the timeline.
🔹 Key Strategies:
✔ Anti-inflammatory diet tailored to reduce triggers.
✔ Customized supplements, peptides, and IV therapy to support detox pathways.
✔ Lifestyle modifications like stress management, hydration, and quality sleep.
👉 Why It Matters: Just as it took years for CIRS to develop, the healing process takes time. Patience and commitment are key.
Step 3: Removing Major Toxins (Mold, Lyme, Actinobacteria, Glucans, etc.)
Once the body is stabilized, we introduce targeted treatments to eliminate biotoxins from the system.
🔹 Key Elements of This Phase:
✔ Addition of specific medications and detox agents to remove toxins.
✔ Strict adherence to the regimen is crucial for success.
✔ Monitoring progress through VCS (Visual Contrast Sensitivity) testing.
🛑 Possible Symptoms During Detox:
- Shakes & chills – Stay hydrated and use over-the-counter support like Tylenol.
- Digestive changes – Temporary bloating, loose stools, or constipation are common.
👉 How Long Does This Take? There is no fixed timeframe – the process continues until your body effectively clears toxins and passes the VCS test.
🎉 Milestone Alert: Passing the VCS test is a huge success, marking a major step toward recovery!
Step 4: Upper Respiratory Tract & Nasal Clearing
Many CIRS patients test positive for Methicillin-resistant Staphylococcus species (MRSA) and other pathogens in nasal passages. This step targets the upper respiratory tract to eliminate lingering infections.
🔹 Treatment Approach:
✔ Prescription nasal sprays and antimicrobial agents.
✔ Continued anti-inflammatory support to maintain progress.
👉 Why It Matters: Clearing the nasal passages prevents reinfection and reduces overall inflammatory burden.
Step 5: Gut Restoration & Microbiome Healing
Your gut health is the foundation of overall recovery. Many CIRS patients experience severe gut dysbiosis, affecting nutrient absorption, enzyme production, and immune balance.
🔹 4-Step Gut Healing Protocol:
1️⃣ Remove – Eliminate harmful pathogens.
2️⃣ Rebuild – Strengthen the gut lining with specialized nutrition.
3️⃣ Restore – Introduce diverse, high-quality probiotics and essential gut-support supplements like butyrate.
4️⃣ Sustain – Maintain balance through long-term dietary and lifestyle habits.
👉 Why It Matters: A healthy gut is essential for effective detox, immune balance, and hormone regulation.
Step 6: Deep Environmental & Organic Detox
Now that gut health is stabilized, we eliminate persistent toxins like heavy metals, plastics, and endocrine disruptors that interfere with hormone balance.
🔹 Detoxification Methods:
✔ Chelation therapy (oral, IV, or rectal).
✔ Supplemental support for liver and kidney detox.
✔ Lifestyle strategies to minimize future toxin exposure.
👉 Why It Matters: These toxins disrupt hormones, cause weight gain, and lead to fatigue, making their removal essential for long-term wellness.
Step 7: Hormone Restoration & Balance
CIRS wreaks havoc on hormone regulation, leading to PMS, perimenopause symptoms, PCOS, and other imbalances.
🔹 Hormone Optimization Plan:
✔ Personalized natural or bioidentical hormone therapy.
✔ Targeted herbal and nutritional support for adrenal, thyroid, and sex hormone balance.
✔ Patience is key – full hormone restoration takes months.
👉 Why It Matters: Balanced hormones enhance energy, mood, metabolism, and overall well-being.
Step 8: Water & Electrolyte Balance Restoration
CIRS impacts the kidneys’ ability to regulate fluid and electrolyte balance, leading to:
🚨 Dizziness when standing
🚨 Frequent thirst
🚨 Shocks or irregular blood pressure
🔹 Treatment Includes:
✔ Hydration with electrolyte-rich fluids.
✔ Supportive supplements for kidney function.
✔ Lifestyle modifications to restore vascular health.
👉 Why It Matters: Proper hydration is critical for cellular function, detox, and recovery.
Step 9: Restoring Inflammatory Balance (C3a, C4a, MMP-9 Markers)
Early lab testing for CIRS often shows high inflammatory markers. Now that other systems are stabilized, we address abnormal inflammatory responses.
🔹 Treatment Options:
✔ Natural anti-inflammatory agents.
✔ Prescription immune-modulating therapies if needed.
👉 Why It Matters: Chronic inflammation must be resolved for full recovery and symptom relief.
Step 10: Brain Recovery & VIP Therapy
Now comes the final stage – cementing progress and reversing the genetic expression of CIRS-related damage.
🔹 VIP (Vasoactive Intestinal Peptide) Therapy:
✔ Carefully monitored nasal spray protocol.
✔ Slow dose adjustments under medical supervision.
✔ Potential duration: 3-6 months with breaks in between.
🧬 Final Genetic Testing: We repeat the GENIE test to ensure that harmful genes have been switched off.
👉 Why It Matters: This solidifies recovery and prevents relapse.
🎉 Final Milestone: When all markers are optimized, you’ve officially conquered CIRS!
Next Steps: What’s Next After CIRS Treatment?
Once the body is balanced, we can now focus on weight management, fitness, and long-term health optimization.
💡 Stay on Track with These Essentials:
✅ Prioritize quality sleep
✅ Stay active with a personalized workout plan
✅ Follow an anti-inflammatory diet
✅ Minimize exposure to toxins & environmental triggers
🔹 Need More Help? Check out our Functional GYN video library for additional guidance on CIRS prevention and recovery strategies.
Ready to take control of your health? Book a consultation and learn more about our comprehensive CIRS packages!
True wellness comes from within,
Dr. Gupta